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KMID : 0895420130230010020
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Journal of Korean Society of Occupational and Enviromental Hygiene
2013 Volume.23 No. 1 p.20 ~ p.26
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Human Health Risk Assessment of n-Butyl Glycidyl Ether from Occupational Workplaces
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Moon Hyung-Il
Choi Hyeon-Il
Sin Sae-Mi
Byeon Sang-Hoon
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Abstract
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Objectives : This study was conducted to evaluate the health risk of workers exposed to butyl glycidyl ether to prevent them from developing occupational diseases.
Methods : The workplaces that coat floor with epoxy were selected and the samples were collected and analyzed with NIOSH 1616 Method. We calculate workplace reference concentration using with NOAEL estimated by the study of Anderson et al. in 1978. Risk was calculated by the ratio of exposure to workplace reference concentration. Monte-Carlo simulation was performed to derivate the median, cumulative 90%, and cumulative 95% value by using Crystal Ball.
Results : Butyl glycidyl ether is a skin, eye irritator and can result in central nervous system depression, allergic reaction. NOAEL was 38 ppm and workplace reference concentration was calculated as 0.73 ppm corrected with uncertainty factors. Geometric mean was 1.152 ppm and geometric standard deviation was 1.522 by the workplace environment measurement. The median, cumulative 90%, and cumulative 95% value of risk were calculated as 1.617, 1.934, and 2.092, respectively.
Conclusions : Not only cumulative 90% and cumulative 95% value but also the median of risk is higher than 1.0 by the risk characterization, so it can do a lot of harm to workers. Therefore, the process of derivating workplace reference concentration and the appropriacy of the uncertainty factors should be re-examined.
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KEYWORD
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risk assessment, butyl glycidyl ether, workplace reference concentration, NOAEL, monte-carlo simulation
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